DHEA

Catabolism and Anabolism in respect to hormones

What is so interesting in CFS is that the body realizes that in favoring “catabolism” requires that there be immunosuppression lest there be too much oxidative stress and when favoring “anabolism” there can be immunactivation as the oxidative stress is under better control if you combine anabolism (aka NADPH and increased GSH) with immunoactivation. The exceptions appear to be estrogen and progesterone, at least on ETM, and my guess is that they are not as catabolically or anabolically active as Cortisol and DHEA, respectively, but are very immunoactive. What is not as clear to me is whether Vitamin D is “catabolic” and Melatonin is “anabolic”.

DHEA, Vitamin D and CFS

This post discusses the interaction of a putatively decoupled P450 system in CFS with Vitamin D and the use of DHEA to increase NADPH and re-couple P450 as observed by ETM